Effective Date: May 2023

Please read the following terms and conditions of use (the “Terms of Use”) carefully before using this website or its subdomains (this “Website”). Your use of this Website is subject to, and constitutes acceptance of, the conditions included in these Terms of Use. If you do not agree to these Terms of Use, you should exit this Website now.

Click on the links below to jump to sections of the Terms of Use:

General

This Website is provided by Vertex Pharmaceuticals Incorporated (“Vertex”) for information purposes. Nothing on this Website should be construed as an offer to form a binding contract, or as granting any license or transfer of intellectual property. Your use of this site is at your own risk. Notwithstanding any other provision herein, Vertex reserves the right, in the event of a violation of these Terms of Use, to protect its rights, property and interests to the maximum extent of the law. Further, Vertex may suspend, discontinue or modify the Website at any time for any reason, without notice or any other obligation to you.

Dated Information

While Vertex may periodically update or correct information presented on this Website, the information presented on this Website may include typographical errors and/or technical inaccuracies and/or omissions. Vertex makes no representation or warranty as to the accuracy of any information at this Website and expressly disclaims any obligation to update such information. Vertex also reserves the right to make additions, deletions or modifications to any information on the Website at any time and from time to time without any prior notice.

Forward-Looking Statements

This Website contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding: information pertaining to our products and the ongoing discovery, development and commercialization of our product candidates; our expectations regarding clinical trials, development timelines and discussions with regulatory authorities related to product candidates under development by us and our collaborators; our expectations about the number of patients that will be evaluated, the anticipated date by which enrollment will be completed and the data that will be generated by ongoing and planned clinical trials, and the ability to use that data for the design and initiation of further clinical trials; our expectations regarding the scope and timing of ongoing and potential future clinical trials; and our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans and objectives. Without limiting the foregoing, the words “believes,” “anticipates,” “plans,” “expects,” “intends,” “outlook,” “forecast” and similar expressions are intended to identify forward-looking statements. While we believe the forward-looking statements contained in this Website are accurate, there are a number of risks and uncertainties that could cause actual events or results to differ materially from those expressed or implied by such forward-looking statements. Those risks and uncertainties include, among other things, that the outcomes for each of our planned clinical trials and studies may not be favorable, that one or more of our internal or external product development programs will not proceed as planned for technical, scientific or commercial reasons, that future competitive or other market factors may adversely affect the commercial potential for our product and/or product candidates, and other risks listed under “Risk Factors” in Vertex’s most recent annual report and subsequent quarterly reports filed with the Securities and Exchange Commission (SEC), and available through this Website and on the SEC’s website at www.sec.gov. None of the information contained herein is intended to be, and shall not be deemed to be, incorporated into any of Vertex’s securities-related filings or statements. You should not place undue reliance on the statements or the scientific data presented on this Website. We disclaim any obligation to update any forward-looking statements contained on this Website as a result of new information, developments occurring after the date such statement was first made or otherwise.

Your Use of the Website

You represent, warrant and covenant that you shall use the Website only as set forth in these Terms of Use. You agree to comply with any other applicable terms and conditions of use set forth on the Website. You may not violate the security of the Website or attempt to gain unauthorized access to the Website or computer systems or networks connected to the Website through any means.

In the event you gain access to information or materials not intended to be accessed by you, you agree that you will immediately notify Vertex and destroy all copies of such information in your possession.

Submission Information

You are solely responsible for any information you send to Vertex, including without limitation accuracy, truthfulness and non-infringement or other violation of any other person's legal rights. Any communication or material that you transmit to our Website by electronic mail or otherwise, including any data, questions, comments, suggestions or the like, is, and will be treated as, non-confidential and nonproprietary information. Vertex and its affiliates may use such communication or material for any purpose including, but not limited to, reproduction, disclosure, transmission, publication, broadcast and further posting. Further, Vertex and its affiliates are free, without payment of compensation to you, to use any ideas, concepts, know-how or techniques contained in any communication or material you send to us, whether through our Website, phone, e-mail or otherwise, for any purpose.

Privacy

If you submit any information (including personal information) at this Website, such information will be subject to the Vertex privacy policy, which is available at https://www.vrtx.com/international-privacy. The sender of any information to Vertex is solely responsible for its content, including, without limitation, its accuracy, truthfulness and non-infringement of any laws or other person's legal rights, including with respect to privacy.

Disclaimer

Any medical information contained on this Website is general in nature and for informational purposes only. We do not offer medical diagnosis or treatment from this Website, and none of the information contained on this Website should be construed as providing medical advice or services of any kind. You should not use the information contained herein for diagnosing a health problem or disease; Vertex makes no representations or warranties as to its accuracy.

Your use of this Website and any linked websites is at your own risk. Neither Vertex not its affiliates or any other party involved in creating, producing or delivering this Website shall be liable for any direct, indirect, incidental or consequential damages arising out of your access to, or use of, this Website or any linked website. This includes damage due to viruses or other harmful or malicious code that may infect your computer equipment.

WITHOUT LIMITING THE FOREGOING, EVERYTHING AT THIS WEBSITE IS PROVIDED TO YOU "AS IS" WITHOUT WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT. SPECIFICALLY, BUT WITHOUT LIMITATION VERTEX DOES NOT WARRANT THAT: (A) THE MATERIALS, FUNCTIONS OR SERVICES PROVIDED BY THIS WEBSITE WILL BE UNINTERRUPTED OR ERROR-FREE; (B) DEFECTS WILL BE CORRECTED; OR (C) THAT THIS WEBSITE OR THE SERVER(S) THAT MAKES IT AVAILABLE ARE FREE OF VIRUSES OR OTHER HARMFUL COMPONENTS.

VERTEX AND ITS AFFILIATES AND LICENSORS CANNOT AND DO NOT GUARANTEE THAT ANY PERSONAL INFORMATION SUPPLIED BY YOU TO VERTEX THROUGH THE WEBSITE (OR THE CONTACT INFORMATION ON THE WEBSITE) WILL NOT BE MISAPPROPRIATED, INTERCEPTED, DELETED, DESTROYED OR USED BY OTHERS.

VERTEX’S AGGREGATE LIABILITY FOR ALL CLAIMS ARISING FROM YOUR ACCESS TO OR USE OF THE WEBSITE SHALL NOT EXCEED $1.00.

Because some jurisdictions do not permit certain limitations or disclaimers of liability, some of the above limitations may not apply to you.

Applicable Law

This Website can be accessed from every U.S. state, as well as from other countries around the world. Each of those places has laws that may differ from those of Massachusetts, where Vertex is located. By accessing this Website you and Vertex agree that the laws of the Commonwealth of Massachusetts, without regard to its conflicts of laws principles, will apply to all disputes based on, arising out of, or relating to your use of this Website or any information it contains. With respect to such disputes, you and Vertex also agree and hereby submit to the exclusive personal jurisdiction and venue of any court located in Boston, Massachusetts.

Changes to This Notice

Vertex may revise these terms at any time without prior notice, which shall be effected by posting of the updated Terms of Use to this Website; provided that any such changes shall only apply to your use of this Website after the date of such change, unless you expressly accept retroactive application of such changes, via click-through, signed agreement or otherwise. You should visit this page each time you access this Website to review the then-current conditions applicable to your use of this Website.

Miscellaneous

We and you are independent contractors and are not partners, joint venturers, agents, employees or representatives of the other party. The headings and captions used in these Terms of Use are used for convenience only and are not to be considered in construing or interpreting these Terms of Use. If any part of these Terms of Use is held to be unlawful, void or unenforceable, that part will be deemed severable and shall not affect the validity and enforceability of the remaining provisions.

Additional Information

If you have any questions about these Terms of Use, please contact us at: Vertex Pharmaceuticals Incorporated, 50 Northern Avenue Boston, MA 02210 or via www.vrtx.com/contact-us.

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