About Cystic Fibrosis

A rare, but fatal, genetic disease with no cure1,2

In 1989, a team of international researchers led by Canadian Dr. Lap-Chee Tsui at The Hospital for Sick Children in Toronto discovered the gene that causes cystic fibrosis.3 Cystic fibrosis is a disease that is caused by a defect in a single gene, called the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The CFTR gene produces the CFTR protein, which works like a channel or gate that allows chloride ions to pass across the cell surface. This keeps a balance of salt and water in the body.1,4

  1. Cystic Fibrosis Canada. The Canadian Cystic Fibrosis Registry: 2017 Annual Report. Available at: https://www.cysticfibrosis.ca/our-programs/cf-registry. Accessed June 25, 2019
  2. National Organization for Rare Disorders. Cystic Fibrosis. Available at: https://rarediseases.org/rare-diseases/cystic-fibrosis/. Accessed June 25, 2019
  3. The Hospital for Sick Children. 25 years later: the impact of the cystic fibrosis gene discovery. Available at: http://www.sickkids.ca/aboutsickkids/newsroom/past-news/2014/25-years-later-the-impact-of-the-cystic-fibrosis-gene-discovery.html. Accessed June 25, 2019.
  4. Orenstein DM. Fibrosis: A Guide for Patient and Family. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004.

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